Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin.

Abstract

Cytochrome P450 (CYP) enzymes, which metabolize numerous drugs, are expressed both in liver and in extrahepatic tissues. CYP3A4 for example is present and inducible by rifampin in epithelial cells of the gastrointestinal tract. It has been shown that such prehepatic metabolism contributes substantially to total clearance of CYP3A4 substrates (e.g… (More)

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Cite this paper

@article{Fromm1996DifferentialIO, title={Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin.}, author={Martin F. Fromm and Dagmar Busse and Heyo Klaus Kroemer and Michel F Eichelbaum}, journal={Hepatology}, year={1996}, volume={24 4}, pages={796-801} }