Differential induction of pS2 and cathepsin D mRNAs by structurally altered estrogens.

@article{Pilat1993DifferentialIO,
  title={Differential induction of pS2 and cathepsin D mRNAs by structurally altered estrogens.},
  author={Mary Jo Pilat and Mikehl S. Hafner and Leos G. Kral and S. Courtnie Brooks},
  journal={Biochemistry},
  year={1993},
  volume={32 27},
  pages={7009-15}
}
The influence of structural alterations to the estradiol-17 beta (E2) molecule on the induction of pS2 and Cathepsin D (Cath D) mRNAs has been examined by Northern analysis of RNA extracted from MCF-7 cells. Exposure of cultures to estratriene did not affect the level of expression of these estrogen-responsive genes. Addition of one hydroxyl group to estratriene at either of the hydroxylated positions of E2 (3-phenolic or 17 beta) yielded monohydroxyestrogens which stimulated the synthesis of… CONTINUE READING