Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.

@article{Zhan1995DifferentialIO,
  title={Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.},
  author={Yuliang Zhan and Christina Cheers},
  journal={Infection and immunity},
  year={1995},
  volume={63 2},
  pages={720-3}
}
Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines. 

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