Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids.

@article{BishopBailey1998DifferentialIO,
  title={Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids.},
  author={David Bishop-Bailey and John R. Pepper and Simon W. Larkin and Jane A Mitchell},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1998},
  volume={18 10},
  pages={1655-61}
}
Two isoforms of cyclooxygenase (COX) have been identified: a constitutive isoform (COX-1), found in abundance in platelets and the vascular endothelium, and an "inflammatory" cytokine-inducible isoform (COX-2). Because COX metabolites regulate vascular smooth muscle cell (SMC) function and the interaction between the vessel and circulating components, we… CONTINUE READING