Differential induction of chromosomal instability by DNA strand-breaking agents.

  title={Differential induction of chromosomal instability by DNA strand-breaking agents.},
  author={Charles L. Limoli and Mark I Kaplan and John W. Phillips and Gerald M. Adair and William F. Morgan},
  journal={Cancer research},
  volume={57 18},
To investigate the role of DNA strand breakage as the molecular lesion responsible for initiating genomic instability, five different strand-breaking agents, bleomycin, neocarzinostatin, hydrogen peroxide, restriction endonucleases, and ionizing radiation, were examined for their capacity to induce delayed chromosomal instability. These studies used GM10115 human-hamster hybrid cells, which contain one copy of human chromosome 4 in a background of 20-24 hamster chromosomes. Chromosomal… CONTINUE READING
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Genomic instability : Initiation and perpetuation

  • L. Limoli.C., F. Morgan.W.
  • Tenth International Congress on Radiation…
  • 1995

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