Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.

@article{Janssen1997DifferentialIO,
  title={Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.},
  author={Yvonne M. W. Janssen and Shabtay Matalon and Brooke T. Mossman},
  journal={The American journal of physiology},
  year={1997},
  volume={273 4 Pt 1},
  pages={L789-96}
}
Reactive oxygen (ROS) or nitrogen (RNS) species can affect epithelial cells to cause acute damage and an array of pulmonary diseases. The goal of this study was to determine patterns of early response gene expression and functional end points of exposure to nitric oxide (NO.), H2O2, or peroxynitrite (ONOO-) in a line of rat lung epithelial (RLE) cells. Our focus was on c-fos and c-jun protooncogenes, as these genes play an important role in proliferation or apoptosis, possible end points of… CONTINUE READING

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