Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.

@article{Knowles1990DifferentialIO,
  title={Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.},
  author={Richard Graham Knowles and Martin C Merrett and Mark Salter and Salvador Moncada},
  journal={The Biochemical journal},
  year={1990},
  volume={270 3},
  pages={833-6}
}
Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation. 

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