Differential induction of bidirectional long-term changes in neurotransmitter release by frequency-coded patterns at the cerebellar input.

@article{DErrico2009DifferentialIO,
  title={Differential induction of bidirectional long-term changes in neurotransmitter release by frequency-coded patterns at the cerebellar input.},
  author={Anna D'Errico and Francesca Prestori and Egidio D'Angelo},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 24},
  pages={5843-57}
}
Sensory stimulation conveys spike discharges of variable frequency and duration along the mossy fibres of cerebellum raising the question of whether and how these patterns determine plastic changes at the mossy fibre-granule cell synapse. Although various combinations of high-frequency bursts and membrane depolarization can induce NMDA receptor-dependent long-term depression (LTD) and long-term potentiation (LTP), the effect of different discharge frequencies remained unknown. Here we show that… CONTINUE READING
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