Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives.

@article{Jin2009DifferentialIO,
  title={Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives.},
  author={Jun-O Jin and Valeria V. Shastina and Joo-In Park and Jin Yeong Han and Tatyana N Makarieva and Sergey N. Fedorov and Valery A. Rasskazov and Valentin A Stonik and Jong-Young Kwak},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 6},
  pages={955-62}
}
Two-headed sphingolipids bear a certain similarity with sphingolipids in the structure and but differing from classical sphingolipids in alpha,omega-position of the basic groups. We analyzed the apoptotic effects of some two-headed sphingolipids including rhizochalin (Rhz) and its derivatives isolated from sponge Rhizochalina incrustata on human leukemia HL-60 cells. Direct addition of Rhz induced apoptosis of HL-60 cells. The aglycon of Rhz, which has no galactosyl residue, showed a stronger… CONTINUE READING
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