Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.

  title={Differential induction of CD38 expression by TNF-\{alpha\} in asthmatic airway smooth muscle cells.},
  author={Joseph A. Jude and Julian Solway and Reynold A Panettieri and Timothy F. Walseth and Mathur S Kannan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={299 6},
The ADP-ribosyl cyclase activity of CD38, a membrane protein expressed in human airway smooth muscle (ASM) cells, generates cyclic ADP-ribose (cADPR), a Ca²(+)-mobilizing agent. cADPR-mediated Ca²(+) responses to agonists are augmented in human ASM cells by TNF-α. CD38-deficient mice fail to develop airway hyperresponsiveness following intranasal TNF-α or IL-13 challenge, suggesting a role in asthma. The role of CD38 in human asthma remains unknown. We hypothesized that CD38 expression will be… CONTINUE READING
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