Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy.

@article{Berghoff2006DifferentialIO,
  title={Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy.},
  author={Martin Berghoff and Sonja Kilo and Max J Hilz and Roy Freeman},
  journal={Muscle & nerve},
  year={2006},
  volume={33 4},
  pages={494-9}
}
It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)-mediated responses. The nociceptor (flare) response was measured using a laser Doppler device. The sudomotor… CONTINUE READING

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