Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

@article{CrdobaChacn2014DifferentialIO,
  title={Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.},
  author={Jos{\'e} C{\'o}rdoba-Chac{\'o}n and Manuel D Gahete and Owen P. McGuinness and Rhonda D. Kineman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 10},
  pages={E928-34}
}
A reciprocal relationship between insulin sensitivity and glucose tolerance has been reported in some mouse models and humans with isolated changes in growth hormone (GH) production and signaling. To determine if this could be explained in part by tissue-specific changes in insulin sensitivity, hyperinsulinemic-euglycemic clamps were performed in mice with… CONTINUE READING