Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression.

@article{Calandreau2010DifferentialIO,
  title={Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression.},
  author={Ludovic Calandreau and Carolyn Marquez and Reto Bisaz and Martina Fantin and Carmen Sandi},
  journal={Genes, brain, and behavior},
  year={2010},
  volume={9 8},
  pages={958-67}
}
Previous studies using neuronal cell adhesion molecule (NCAM) -/- knockout (KO) mice provided evidence for a role of NCAMs in social behaviors. However, polysialic acid (PSA), the most important post-translational modification of NCAM, was also absent in these mice, which makes it difficult to distinguish between the specific involvement of either PSA or NCAM in social interactions. To address this issue, we assessed two lines of mice deficient for one of the two sialyltransferase enzymes… CONTINUE READING
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