Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome.

@article{SellierLeclerc2007DifferentialIO,
  title={Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome.},
  author={Anne-Laure Sellier-Leclerc and V{\'e}ronique Fr{\'e}meaux-Bacchi and Marie-Agn{\`e}s Dragon-Durey and M S Macher and Patrick Niaudet and Genevi{\`e}ve Guest and Bernard R. Boudailliez and François Bouissou and Georges Desch{\^e}nes and Sophie Gi{\'e} and Michel Tsimaratos and Michel Fischbach and Denis Morin and Hubert Nivet and Corinne Alberti and Chantal Loirat},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 8},
  pages={2392-400}
}
Mutations in factor H (CFH), factor I (IF), and membrane cofactor protein (MCP) genes have been described as risk factors for atypical hemolytic uremic syndrome (aHUS). This study analyzed the impact of complement mutations on the outcome of 46 children with aHUS. A total of 52% of patients had mutations in one or two of known susceptibility factors (22, 13, and 15% of patients with CFH, IF, or MCP mutations, respectively; 2% with CFH+IF mutations). Age <3 mo at onset seems to be characteristic… CONTINUE READING
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TH: CLINICAL RESEARCH www.jasn.org

  • G Filler, S Radhakrishnan, L Strain, A Hill, G Knoll, Goodship
  • J Am Soc Nephrol
  • 2007

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