Differential immunotoxicity of histone deacetylase inhibitors on malignant and naïve hepatocytes.

@article{Weiller2011DifferentialIO,
  title={Differential immunotoxicity of histone deacetylase inhibitors on malignant and na{\"i}ve hepatocytes.},
  author={Markus Weiller and Timo Weiland and Georg Duenstl and Ulrike Sack and Gerald K{\"u}nstle and Albrecht Wendel},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2011},
  volume={63 5},
  pages={511-7}
}
Histone deacetylases (HD) represent a novel target in cancer treatment, particularly for scattered small tumours such as the hepatocellular carcinoma (HCC). However, only few studies address the toxicological impact of HD Inhibitors (HDIs) on malignantly transformed cells versus primary hepatocytes. We examined whether and how different classes of HDIs… CONTINUE READING