Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol.

@article{Petitto1990DifferentialIR,
  title={Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol.},
  author={John M. Petitto and T D McIntyre and Bradford L. McRae and Phil Skolnick and Prince K. Arora},
  journal={Brain, behavior, and immunity},
  year={1990},
  volume={4 1},
  pages={39-49}
}
Natural killer cell activity was compared in the Long-Sleep and Short-Sleep mouse lines. These mice, initially selected for their sensitivities to a hypnotic dose of ethanol, are also differentially sensitive to other agents which act through the benzodiazepine/GABA receptor chloride ionophore complex. Natural killer cell activity was 40-59% lower in Short-Sleep when compared to Long-Sleep mice. Flow cytofluorometric analysis demonstrated that the number of Nk-1+ cells was also lower in the… CONTINUE READING