Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines.

@article{Tarn1999DifferentialIE,
  title={Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines.},
  author={Chi Tarn and Matthew L. Bilodeau and Ronald L. Hullinger and Ourania M Andrisani},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 4},
  pages={2327-36}
}
We report construction and characterization of tetracycline-controlled hepatitis B virus pX-expressing hepatocyte (AML12) cell lines. These cell lines were constructed in AML12 clonal isolates (clones 3 and 4), which express constitutively the tetracycline-controlled transactivator. Since pX is implicated in HCC, this immortalized hepatocyte model system… CONTINUE READING