Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine.

@article{Stenstad2007DifferentialHM,
  title={Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine.},
  author={Hanna Stenstad and Marcus Svensson and Helena Cucak and Knut Kotarsky and William W. Agace},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 24},
  pages={10122-7}
}
The CC chemokine receptor (CCR)9 is expressed on the majority of small intestinal, but few colonic, T cells, whereas its ligand CCL25 is constitutively expressed by small intestinal epithelial cells. As such, CCR9/CCL25 have been proposed to play a central role in regulating small intestinal but not colonic immune responses and thus to organize regionalized immunity within the intestinal mucosa. Here, we demonstrate that CCL25 is expressed at reduced levels by epithelial cells in the distal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…