Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

@inproceedings{Kubota2016DifferentialHD,
  title={Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity},
  author={Naoto Kubota and Tetsuya Kubota and Eiji Kajiwara and Tomokatsu Iwamura and Hiroki Kumagai and Taku Watanabe and Mariko Inoue and Iseki Takamoto and Takayoshi Sasako and Katsuyoshi Kumagai and Motoyuki Kohjima and Makoto Nakamuta and Masao Moroi and Kaoru Sugi and Tetsuo Noda and Yasuo Terauchi and Kohjiro Ueki and Takashi Kadowaki},
  booktitle={Nature communications},
  year={2016}
}
  • Naoto Kubota, Tetsuya Kubota, +15 authors Takashi Kadowaki
  • Published in Nature communications 2016
  • Medicine, Biology
  • Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes and obesity, insulin no longer suppresses hepatic gluconeogenesis, while continuing to activate lipogenesis, a state referred to as 'selective insulin resistance'. Here, we show that 'selective insulin resistance' is caused by the differential expression of Irs1 and Irs2 in different zones of the liver. We… CONTINUE READING

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