Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells.

@article{Zhang2007DifferentialGI,
  title={Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells.},
  author={Manchao Zhang and Hongpeng Liu and Zhenkun Tian and Jenny Y. Huang and Mylene Remo and Qingdi Quentin Li},
  journal={Clinical and experimental pharmacology & physiology},
  year={2007},
  volume={34 3},
  pages={
          230-7
        }
}
1. Bax is a very important pro-apoptosis molecule. HCT116/Bax(-/-) cells do not express the pro-apoptosis Bcl-2 family member, Bax. In the present study, the anticancer effects of gossypol on HCT116 and HCT116/Bax(-/-) cells were compared in terms of inhibition of cell growth, inhibition of colony formation and induction of apoptosis. 2. Following treatment with concentrations more than 20 micromol/L gossypol, only slight differences (not significant) were seen between HCT116 and HCT116/Bax… CONTINUE READING
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