Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. Keloid-derived and fetal fibroblasts are refractory to down-regulation.

@article{Russell1989DifferentialGR,
  title={Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. Keloid-derived and fetal fibroblasts are refractory to down-regulation.},
  author={Shirley B Russell and J S Trupin and Jeanne C. Myers and A H Broquist and Julie C. Smith and Marvin E. Myles and James D. Russell},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 23},
  pages={13730-5}
}
Abnormal regulation of collagen synthesis has been observed in fibroblasts from keloids, benign collagenous tumors that develop as a result of an inherited defect in dermal wound healing. Hydrocortisone reduces the rate of collagen synthesis in fibroblasts from normal adult dermis and scars, but fails to down regulate collagen synthesis in keloid-derived fibroblasts. We show here that loss of glucocorticoid control of collagen synthesis in keloid cells is due to an inability of hydrocortisone… CONTINUE READING

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Collagen Acad . Dermatol . 4 , 461470 Physiol . 109 , 121131 ( Rock ~ itole ) 18 , 557564 R & tI Res

  • J. D. Russell, J. S. Trupin
  • 1983

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