Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

@article{Mogil1996DifferentialGM,
  title={Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.},
  author={Jeffrey S Mogil and Benjamin Kest and Bogdan Sadowski and John K. Belknap},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={276 2},
  pages={532-44}
}
Several genetic mouse models of opiate sensitivity have been identified or produced in an attempt to investigate mechanisms underlying individual variation in responses to opiate drugs like morphine. The major models in use presently are the DBA/2 (DBA) versus C57BL/6 (C57) inbred strains, the recombinantly inbred CXBK strain, and mouse lines selectively bred for high- and low-magnitude antinociception after swim stress (HA and LA lines, respectively) or levorphanol administration (HAR and LAR… CONTINUE READING