Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.

@article{Ioannidis2004DifferentialGE,
  title={Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.},
  author={John P. A. Ioannidis and Stuart H. Ralston and Simon T. Bennett and Maria Luisa Brandi and Daniel Grinberg and Fotini B. Karassa and Bente Lomholt Langdahl and Joyce B. J. van Meurs and Leif Mosekilde and Serena A. Scollen and Omar M. E. Albagha and Mariona Bustamante and Alisoun H. Carey and Alison M. Dunning and Anna Enjuanes and Johannes P. T. M van Leeuwen and Carmelo Mavilia and Laura Masi and F E McGuigan and Xavier Nogu{\'e}s and Huibert A. P. Pols and David M. Reid and Stephanie Schuit and Rachael E Sherlock and Andr{\'e} G. Uitterlinden},
  journal={JAMA},
  year={2004},
  volume={292 17},
  pages={2105-14}
}
CONTEXT Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results. OBJECTIVE To generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1 polymorphisms XbaI [dbSNP: rs9340799] and PvuII [dbSNP: rs2234693] and promoter TA repeats… CONTINUE READING

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trogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women

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