Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2.

@article{Li2002DifferentialGR,
  title={Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2.},
  author={Yong Li and Mitchell A Lazar},
  journal={Molecular endocrinology},
  year={2002},
  volume={16 5},
  pages={1040-8}
}
The PPARgamma is a key adipogenic determination factor. Ligands for PPARgamma such as antidiabetic thiazolidinedione (TZD) compounds are adipogenic, and many adipocyte genes that are activated by TZDs contain binding sites for PPARgamma. Like ligands for other nuclear receptors, TZDs can regulate genes positively or negatively. Here, we sought to understand the importance of positive regulation of gene expression by PPARgamma in adipogenesis. Fusion of the potent viral transcriptional activator… CONTINUE READING

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