Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome.

Abstract

Prader-Willi syndrome (PWS) is a genetic disorder caused by deficiency of imprinted gene expression from the paternal chromosome 15q11-15q13 and clinically characterized by neonatal hypotonia, short stature, cognitive impairment, hypogonadism, hyperphagia, morbid obesity, and diabetes. Previous clinical studies suggest that a defect in energy metabolism may… (More)
DOI: 10.1111/cts.12083

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@article{Yazdi2013DifferentialGE, title={Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome.}, author={Puya G. Yazdi and Hailing Su and Svetlana D. Ghimbovschi and Weiwei Fan and Pinar E. Coskun and Ang{\`e}le Nalbandian and Susan Knoblach and James L. Resnick and Eric A Hoffman and Douglas C. Wallace and V Kimonis}, journal={Clinical and translational science}, year={2013}, volume={6 5}, pages={347-55} }