Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.

@article{Juric2007DifferentialGE,
  title={Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.},
  author={Dejan Juric and Norman J. Lacayo and Meghan C Ramsey and Janis Racevskis and Peter H. Wiernik and Jacob M. Rowe and Anthony H. Goldstone and Peter J. O'dwyer and Elisabeth Paietta and Branimir Sikic},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2007},
  volume={25 11},
  pages={1341-9}
}
PURPOSE To identify gene expression patterns and interaction networks related to BCR-ABL status and clinical outcome in adults with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS DNA microarrays were used to profile a set of 54 adult ALL specimens from the Medical Research Council UKALL XII/Eastern Cooperative Oncology Group E2993 trial (21 p185BCR-ABL-positive, 16 p210BCR-ABL-positive and 17 BCR-ABL-negative specimens). RESULTS Using supervised and unsupervised analysis tools, we… CONTINUE READING
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