Differential gene expression of soluble CD8+ T-cell mediated suppression of HIV replication in three older children.

@article{Katz2011DifferentialGE,
  title={Differential gene expression of soluble CD8+ T-cell mediated suppression of HIV replication in three older children.},
  author={Ben Zion Katz and Babak Salimi and Samantha L Gadd and Chiang-Ching Huang and William J Kabat and Donna S. Kersey and Christopher J McCabe and Taylor Heald-Sargent and Elyssa D Katz and Ram Yogev},
  journal={Journal of medical virology},
  year={2011},
  volume={83 1},
  pages={24-32}
}
Suppression of human immunodeficiency virus (HIV) replication by CD8+ T-cells (CD8 suppression) contributes to survival in adults and children <1 year. Soluble CD8 suppression can also be seen in some older children with AIDS. The factor responsible, CD8-derived antiviral factor (CAF), acts at the level of HIV RNA transcription. Differential gene expression techniques have been used to define the gene(s) mediating this phenomenon in adults. Recently, CAF has been linked to exosomes secreted by… CONTINUE READING