Differential gene expression of organic anion transporters in male and female rats.

  title={Differential gene expression of organic anion transporters in male and female rats.},
  author={Yasuna Kobayashi and Noriko Hirokawa and Naomi Ohshiro and Takashi Sekine and Tadanori Sasaki and Shogo Tokuyama and Hitoshi Endou and Toshinori Yamamoto},
  journal={Biochemical and biophysical research communications},
  volume={290 1},
Sex-related differential gene expression of organic anion transporters (rOAT1, rOAT2, and rOAT3) in rat brain, liver, and kidney was investigated. There were no sex differences in the expression of rOAT1 mRNA. rOAT2 mRNA was abundant in the liver and weakly expressed in the kidney of male rats; however, the OAT2 gene was strongly expressed in both organs of females. The abundance of rOAT2 mRNA markedly increased in castrated male rat kidney; however, treatment of castrated male rats with… CONTINUE READING


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