Differential gene expression of medullary thyroid carcinoma reveals specific markers associated with genetic conditions.

Abstract

Medullary thyroid carcinoma accounts for 2% to 5% of thyroid malignancies, of which 75% are sporadic and the remaining 25% are hereditary and related to multiple endocrine neoplasia type 2 syndrome. Despite a genotype-phenotype correlation with specific germline RET mutations, knowledge of pathways specifically associated with each mutation and with non-RET… (More)
DOI: 10.1016/j.ajpath.2012.10.025

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