Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells.

@article{Seidel1999DifferentialGE,
  title={Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells.},
  author={Shawn D Seidel and Michael S. Denison},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={1999},
  volume={52 2},
  pages={217-25}
}
The aryl hydrocarbon nuclear translocator (Arnt) is a basic helix-loop-helix (per/Arnt/Ahr/sim) PAS-containing protein that can heterodimerize with the aryl hydrocarbon receptor (AhR), the hypoxia-inducible factor-1 alpha, and other PAS-containing proteins to form transcriptionally active complexes. To identify the genes whose expression is modulated by Arnt, we used the technique of differential display to compare the expression of genes in wild-type and Arnt-defective (BPRc1) mouse hepatoma… CONTINUE READING