Differential gene expression in response to ventricular unloading in rat and human myocardium.

UNLABELLED Left ventricular unloading by mechanical assist devices induces myocardial atrophy. We aimed to systematically identify differentially expressed genes in a model of physiological atrophy (unloading of healthy rat myocardium) and compare these changes to those in a unloaded, failing human heart. METHODS Atrophy in rat hearts was induced by… (More)