Differential gene expression in periportal and perivenous mouse hepatocytes.

  title={Differential gene expression in periportal and perivenous mouse hepatocytes.},
  author={Albert Braeuning and Carina Ittrich and Christoph T K{\"o}hle and Stephan Hailfinger and Michael Bonin and Albrecht Buchmann and Michael Schwarz},
  journal={The FEBS journal},
  volume={273 22},
Hepatocytes located in the periportal and perivenous zones of the liver lobule show remarkable differences in the levels and activities of various enzymes and other proteins. To analyze global gene expression patterns of periportal and perivenous hepatocytes, enriched populations of the two cell types were isolated by combined collagenase/digitonin perfusion from mouse liver and used for microarray analysis. In total, 198 genes and expressed sequences were identified that demonstrated a >/= 2… CONTINUE READING
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