Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites.

  title={Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites.},
  author={Diana Villarreal and Philippe Nird{\'e} and Mallorie Hide and Christian Barnab{\'e} and Michel Tibayrenc},
  journal={Antimicrobial agents and chemotherapy},
  volume={49 7},
We analyzed the differential gene expression among representative Trypanosoma cruzi stocks in relation to benznidazole exposures using a random differentially expressed sequences (RADES) technique. Studies were carried out with drug pressure both at the natural susceptibility level of the wild-type parasite (50% inhibitory concentration for the wild type) and at different resistance levels. The pattern of differential gene expression performed with resistant stocks was compared to the… CONTINUE READING


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Genetic diversity and drug resistance in Trypanosoma cruzi, the agent of Chagas disease

  • M.J.O. Toledo, W. L. Tafuri, M. T. Bahia, M. Tibayrenc, M. Lana
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