Differential gene expression between normal and tumor-derived ovarian epithelial cells.

@article{Ismail2000DifferentialGE,
  title={Differential gene expression between normal and tumor-derived ovarian epithelial cells.},
  author={Rubina S. Ismail and R L Baldwin and J Fang and D Browning and B Y Karlan and Judith C. Gasson and David D. Chang},
  journal={Cancer research},
  year={2000},
  volume={60 23},
  pages={6744-9}
}
The majority of ovarian tumors arise from the transformation of the ovarian surface epithelial cells, a single layer of cells surrounding the ovary. To identify genes that may contribute to the malignant phenotype of ovarian cancers, cDNA representational difference analysis was used to compare expressed genes in primary cultures of normal human ovarian surface epithelium (HOSE) and ovarian tumor-derived epithelial cells from the Cedars-Sinai Ovarian Cancer (CSOC) repository. A total of 255… CONTINUE READING