Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defence.

@article{Doyle2010DifferentialGE,
  title={Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defence.},
  author={Ian Doyle and Marianne Ratcliffe and Andrew Walding and Elizabeth J Vanden Bon and Michael Dymond and Wendy Tomlinson and David Tilley and Philip Shelton and Iain G. Dougall},
  journal={Molecular immunology},
  year={2010},
  volume={47 5},
  pages={1058-65}
}
Alveolar macrophages have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). In this setting they are routinely exposed to cigarette smoke and a range of pathogens including bacteria and viruses. The gene expression changes that result from these challenges may contribute to the initiation and progression of the disease. Understanding such changes is therefore of great interest and could aid the discovery of novel therapeutics. To study this, we stimulated… CONTINUE READING

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