Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.

@article{Haase2007DifferentialGE,
  title={Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.},
  author={Hajo Haase and Dawn Mazzatti and Andrew J P White and Klaus H Ibs and Gabriela Engelhardt and Silke Hebel and Jonathan R Powell and Lothar Rink},
  journal={Molecular medicine},
  year={2007},
  volume={13 7-8},
  pages={
          362-70
        }
}
An individual's zinc status has a significant impact on the immune system, and zinc deficiency, as well as supplementation, modulates immune function. To investigate the effects of zinc on different leukocyte subsets, we used microarray technology to analyze and compare the changes in mRNA expression in cell culture models of monocytes (THP-1), T cells (Jurkat), and B cells (Raji), in response to supplementation for 40 h with 50 microM zinc or 2.5 microM of the membrane-permeant zinc chelator… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…