Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.

@article{Duit2010DifferentialFO,
  title={Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.},
  author={Sarah Duit and Harald Mayer and Sophia M Blake and Wolfgang Johann Schneider and Johannes Nimpf},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 7},
  pages={4896-908}
}
ApoER2 and very low density lipoprotein (VLDL) receptor transmit the Reelin signal into target cells of the central nervous system. To a certain extent, both receptors can compensate for each other, and only the loss of both receptors results in the reeler phenotype, which is characterized by a gross defect in the architecture of laminated brain structures. Nevertheless, both receptors also have specific distinct functions, as corroborated by analyses of the subtle phenotypes displayed in mice… CONTINUE READING

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Distinct Functions of ApoER2 and VLDL Receptor

  • B. W. Howell, T. M. Herrick, J. D. Hildebrand, Y. Zhang, Cooper
  • FEBRUARY 12,
  • 2010

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