Differential functional role of purinergic and nitrergic inhibitory cotransmitters in human colonic relaxation.

@article{Ma2014DifferentialFR,
  title={Differential functional role of purinergic and nitrergic inhibitory cotransmitters in human colonic relaxation.},
  author={Noem{\'i} Ma{\~n}{\'e} and Vict{\`o}ria Villalta Gil and M{\'i}riam Mart{\'i}nez-Cutillas and Pere Clav{\'e} and Diana Gallego and Marcel Jimenez},
  journal={Acta physiologica},
  year={2014},
  volume={212 4},
  pages={
          293-305
        }
}
AIM ATP and nitric oxide (NO) are released from enteric inhibitory motor neurones and are responsible for colonic smooth muscle relaxation. However, how frequency of neural stimulation affects this cotransmission process and the post-junctional responses has not been systematically characterized in the human colon. METHODS The dynamics of inhibitory cotransmission were studied using different protocols of electrical field stimulation (EFS) to characterize the inhibitory junction potentials… CONTINUE READING

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