Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man.

@article{Ladona1991DifferentialFD,
  title={Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man.},
  author={M G Ladona and B O Lindstr{\"o}m and Charlotte Thyr and P Dun-Ren and Anders Rane},
  journal={British journal of clinical pharmacology},
  year={1991},
  volume={32 3},
  pages={295-302}
}
1. Codeine and dextromethorphan were N-demethylated in human foetal liver microsomes at high rates which were close to the activities in adult livers. In contrast, foetal liver microsomes did not catalyze the O-demethylation of these drugs at mid-gestation. 2. The metabolic data were in accordance with the absence of P450IID6 and the presence of P450 IIIA as determined by Western blotting with anti-human P450 IID6 (MAb 114/2) and anti-rat P450 IIIA (PCN 2-13-1/C2) monoclonal antibodies… CONTINUE READING

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