Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development.

@article{Aronica2007DifferentialEP,
  title={Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development.},
  author={Eleonora M A Aronica and Karin T. den Boer and Sandra Redeker and Wim G. M. Spliet and Pieter C van Rijen and Dirk G. Troost and Jan A. Gorter},
  journal={Neuroscience},
  year={2007},
  volume={145 1},
  pages={
          185-96
        }
}
Malformations of cortical development are recognized causes of chronic medically intractable epilepsy. An increasing number of observations suggests an important role for cation-chloride co-transporters (CCTs) in controlling neuronal function. Deregulation of their expression may contribute to the mechanisms of hyperexcitability that lead to seizures. In the present study the expression and cell-specific distribution of Na+-K+-2Cl--cotransporter (NKCC1) and K+-Cl--cotransporter (KCC2) were… CONTINUE READING

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