Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol.

@article{Katayama2006DifferentialEP,
  title={Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol.},
  author={Seiichi Katayama and Koji Ashizawa and Tadahiro Fukuhara and Makoto Hiroyasu and Yasuhiro Tsuzuki and Hideki Tatemoto and Tadashi Nakada and Kenji Nagai},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2006},
  volume={91 2},
  pages={419-30}
}
To characterize the effects of an estrogen receptor (ER) agonist on the gene expressions in the uterus, immature female rats were administered once orally with 17alpha-ethynyl estradiol (EE, 3 mug/kg), a potent ER agonist. We focused on four categories of sex steroid hormone receptor genes: well-known estrogen target genes, Wnt genes, and beta-catenin/T-cell factor (TCF) target genes. ERalpha, ERbeta, progesterone receptor, and androgen receptor mRNAs were all downregulated at 24 and/or 48 h… CONTINUE READING
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