Differential expression of transglutaminase in human erythroleukemia cells in response to retinoic acid.

@article{Suedhoff1990DifferentialEO,
  title={Differential expression of transglutaminase in human erythroleukemia cells in response to retinoic acid.},
  author={T Suedhoff and P. J. Birckbichler and Kee Nyung Lee and Eunice Conway and Manford K. Patterson},
  journal={Cancer research},
  year={1990},
  volume={50 24},
  pages={7830-4}
}
Two human erythroleukemia cell lines, HEL and K562, express transglutaminase activity. The enzyme was identified as a tissue transglutaminase following chromatographic purification. All-trans-retinoic acid (10 microM) stimulated differentiation in HEL cells as judged by a 4-fold increase in hemoglobin content and a reduction in cell proliferation. The transglutaminase activity increased 9-fold. This increase in transglutaminase was the result of a pretranslational regulation of the gene as… CONTINUE READING

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Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1991

References

Publications referenced by this paper.
Showing 1-10 of 35 references

A third human retinoic acid receptor, hRAR-gamma.

Proceedings of the National Academy of Sciences of the United States of America • 1989

GTP hydrolysis by guinea pig liver transglutaminase.

Biochemical and biophysical research communications • 1989
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