Differential expression of the versican and decorin genes in photoaged and sun-protected skin. Comparison by immunohistochemical and northern analyses.

@article{Bernstein1995DifferentialEO,
  title={Differential expression of the versican and decorin genes in photoaged and sun-protected skin. Comparison by immunohistochemical and northern analyses.},
  author={Eric F. Bernstein and Larry W. Fisher and Keqin Li and Richard G. LeBaron and Eng M Tan and Jouni Uitto},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1995},
  volume={72 6},
  pages={662-9}
}
BACKGROUND Chronic sun exposure induces numerous changes in exposed skin; the most striking histopathologic change is the massive accumulation of material with the staining characteristics of elastin, termed solar elastosis, in the superficial dermis. Previous studies have identified elastic fibers within areas of solar elastosis, as well as a decrease in collagen content. Recently, the large chondroitin sulfate (CS) proteoglycan, versican, has been identified in the dermis in association with… CONTINUE READING