Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas

@inproceedings{Weigand2017DifferentialEO,
  title={Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas},
  author={Isabel Weigand and Cristina L Ronchi and Marthe Rizk-Rabin and Guido Di Dalmazi and Vanessa Wild and Kerstin Bathon and Beatrice Rubin and Davide Calebiro and Felix Beuschlein and J{\'e}r{\^o}me Bertherat and Martin Fassnacht and Silviu Sbiera},
  booktitle={Scientific Reports},
  year={2017}
}
Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two catalytic and two regulatory subunits with the latter inhibiting PKA activity. The human genome encodes three different PKA catalytic subunits and four different regulatory subunits that are… CONTINUE READING