Differential expression of the metallothionein gene in liver and brain of mice and rats.

@article{Choudhuri1993DifferentialEO,
  title={Differential expression of the metallothionein gene in liver and brain of mice and rats.},
  author={Supratim Choudhuri and James McKim and Curtis D. Klaassen},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={119 1},
  pages={1-10}
}
Expression of the metallothionein I (MT-I) gene was studied in liver and brain of control mice and rats, as well as following administration of Cd and lipopolysaccharide (LPS). Time-course studies revealed that MT mRNA reached a maximum in liver of both mice and rats 6 hr following treatment with Cd or LPS. MT mRNA from control and Cd- and LPS-treated rat brains could not be detected by Northern-blot analysis of total RNA, but Northern analysis with poly(A)-enriched RNA revealed that induction… CONTINUE READING

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