Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival

@article{Doll2010DifferentialEO,
  title={Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival},
  author={Dietrich Doll and Larissa Keller and Matthias Maak and Anne-Laure Boulesteix and Joerg Ruediger Siewert and Bernhard Holzmann and K. P. Janssen},
  journal={International Journal of Colorectal Disease},
  year={2010},
  volume={25},
  pages={573-581}
}
Chemotactic cytokines play a role in angiogenesis and attraction of immune cells. However, their contribution to tumor formation remains incompletely understood. In a previous transcriptome study, we identified a family of structurally related chemokines of the CXC-family to be specifically up-regulated in colorectal cancer. The aim of the present study was to investigate the regulation of their expression in colon cancer cells and to test the hypothesis that altered CXC-chemokine expression is… CONTINUE READING