Differential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals.

@article{Dever2014DifferentialEO,
  title={Differential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals.},
  author={Seth M. Dever and Blair N. Costin and Ruqiang Xu and Nazira El-Hage and Joyce M Balinang and Alexander Samoshkin and Megan A O'Brien and MaryPeace McRae and Luda Diatchenko and Pamela E Knapp and Kurt F Hauser},
  journal={AIDS},
  year={2014},
  volume={28 1},
  pages={19-30}
}
OBJECTIVE We previously examined the expression of specific C-terminal μ-opioid receptor (MOR) splice variants in human central nervous system cell types and HIV-infected brain tissue from individuals with neurocognitive impairment ± HIV encephalitis (HIVE). In the present study, we examined the N-terminal splice variant MOR-1K, which mediates excitatory cellular signaling. METHODS AND RESULTS We found segregation of expression ranging from undetectable to seemingly exclusive across nervous… CONTINUE READING

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