Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer

Abstract

Skp2 is an F-box protein involved in the ubiquitination and subsequent degradation of the cyclin-dependent kinase (Cdk) inhibitor p27. Skp2 has been reported to be overexpressed in a variety of cancer types and to correlate with poor prognosis. We have identified a novel isoform of Skp2 we named Skp2B, which differs from Skp2 only in the C-terminal domain… (More)
DOI: 10.1038/sj.onc.1208328

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