Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours

  title={Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours},
  author={Sylvie Lantu{\'e}joul and Jean – Charles Soria and Denis L Moro-Sibilot and Luc Morat and Sylvie Veyrenc and Philippe Lorimier and P Y Brichon and Laure Sabatier and Christian Brambilla and Elisabeth M Brambilla},
  journal={British Journal of Cancer},
  pages={1222 - 1229}
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading to unlimited cellular proliferation and immortality. To evaluate the prognostic value of the catalytic subunit telomerase reverse transcriptase (hTERT), we analysed its expression by immunohistochemistry in 122 formalin-fixed lung tumours including 42 squamous cell carcinoma (SCC), 43… CONTINUE READING
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