Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells.

Abstract

Most in vitro toxicity studies on engineered nanomaterials (ENMs) use transformed rather than primary cells for logistical reasons. However, primary cells may provide a more appropriate connection to in vivo toxicity because these cells maintain their phenotypic fidelity and are also capable of differentiating into lineages that may be differently affected… (More)
DOI: 10.1021/nn200328m

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Cite this paper

@article{Zhang2011DifferentialEO, title={Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells.}, author={Haiyuan Zhang and Tian Xia and Huan Meng and Min Xue and Saji George and Zhaoxia Ji and Xiang Wang and Rong Liu and Meiying Wang and Bryan France and Robert Rallo and Robert Damoiseaux and Yoram Cohen and Kenneth A. Bradley and Jeffrey I Zink and Andr{\'e} Nel}, journal={ACS nano}, year={2011}, volume={5 4}, pages={2756-2769} }